Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer

Immune checkpoint inhibitor (ICI)-based immunotherapy in triple negative breast cancer (TNBC) is achieving limited therapeutic results, requiring the development of more potent strategies. Combination of ICI with vaccination strategies would enhance antitumor immunity and response rates to ICI in pa...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Belén Aparicio, David Repáraz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Patrick Theunissen, Ibon Tamayo, Cristian Smerdou, Ana Igea, Marta Santisteban, Cristina Gónzalez-Deza, Juan J. Lasarte, Sandra Hervás-Stubbs, Pablo Sarobe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	triple negative breast cancer neoantigens immunogenicity polyepitopic vaccines HLA-A*02:01 epitopes
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.985886/full