Four novel genetic mutations are associated with patent foramen ovale in Tibetan population using whole exome sequencing

ObjectivePatent foramen ovale (PFO), a prevalent congenital cardiac defect, is linked to clinical conditions such as cryptogenic stroke and migraine. The genetic underpinnings of PFO remain poorly elucidated, particularly in Tibet. This study aimed to identify potential pathogenic mutations in Tibet...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Hongwei Li, Yongjun He, Yong Wu, Lanxin Liu, Wei Du, Duika Wang, Zeng He, Liming Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	pathogenetic mutations whole exome sequencing patent foramen ovale Tibetan genetics
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1592306/full