Cholesterol lowering drug may influence cellular immune response by altering MHC II function[S]
Major histocompatibility complex class II (MHC II) expressed on the surface of antigen-presenting cells (APCs) displays peptides to CD4+ T cells. Depletion of membrane cholesterol from APCs by methyl β-cyclodextrin treatment compromises peptide-MHC II complex formation coupled with impaired binding...
| Published in: | Journal of Lipid Research |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-11-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520350628 |