Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent DysfunctionSummary

Background & Aims: Although it is well-known that ribosomes are critical for cell function, and their synthesis (known as ribosome biogenesis [RiBi]) is energy-intensive, surprisingly little is known about RiBi in vivo in adult tissue. Methods: Using a mouse model with conditional deletion o...

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Bibliographic Details

Published in:	Cellular and Molecular Gastroenterology and Hepatology
Main Authors:	Charles J. Cho, Thanh Nguyen, Amala K. Rougeau, Yang-Zhe Huang, Sarah To, Xiaobo Lin, Supuni Thalalla Gamage, Jordan L. Meier, Jason C. Mills
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Ribosome N-Acetyltransferase 10 Nucleolus p53 Paligenosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352345X25000372