A platform technology for ultra-long acting intratumoral therapy

Abstract Intratumoral (IT) therapy is a powerful method of controlling tumor growth, but a major unsolved problem is the rapidity that injected drugs exit tumors, limiting on-target exposure and efficacy. We have developed a generic long acting IT delivery system in which a drug is covalently tether...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Jeff Henise, John A. Hangasky, Deborah Charych, Christopher W. Carreras, Gary W. Ashley, Daniel V. Santi
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Online Access:https://doi.org/10.1038/s41598-024-64261-8