Luteolin protects DYT-PRKRA cells from apoptosis by suppressing PKR activation
DYT-PRKRA is a movement disorder caused by mutations in the PRKRA gene, which encodes for PACT, the protein activator of interferon-induced, double-stranded RNA (dsRNA)-activated protein kinase PKR. PACT brings about PKR’s catalytic activation by a direct binding in response to stress signals and ac...
| Published in: | Frontiers in Pharmacology |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1118725/full |