Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis—a case study using metatranscriptomics

Abstract Background Ileal pouch-anal anastomosis (IPAA) is the standard of care after total proctocolectomy for ulcerative colitis (UC). Around 50% of patients will experience pouchitis, an idiopathic inflammatory condition. Antibiotics are the backbone of treatment of pouchitis; however, antibiotic...

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Bibliographic Details

Published in:	Microbiome
Main Authors:	Zhi-Luo Deng, Dietmar H. Pieper, Andreas Stallmach, Arndt Steube, Marius Vital, Michael Reck, Irene Wagner-Döbler
Format:	Article
Language:	English
Published:	BMC 2023-12-01
Subjects:	Metatranscriptome Fecal microbiota transplantation Pouchitis Engraftment Activity alterations Butyrate biosynthesis
Online Access:	https://doi.org/10.1186/s40168-023-01713-9