Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis—a case study using metatranscriptomics

Abstract Background Ileal pouch-anal anastomosis (IPAA) is the standard of care after total proctocolectomy for ulcerative colitis (UC). Around 50% of patients will experience pouchitis, an idiopathic inflammatory condition. Antibiotics are the backbone of treatment of pouchitis; however, antibiotic...

Full description

Bibliographic Details
Published in:	Microbiome
Main Authors:	Zhi-Luo Deng, Dietmar H. Pieper, Andreas Stallmach, Arndt Steube, Marius Vital, Michael Reck, Irene Wagner-Döbler
Format:	Article
Language:	English
Published:	BMC 2023-12-01
Subjects:	Metatranscriptome Fecal microbiota transplantation Pouchitis Engraftment Activity alterations Butyrate biosynthesis
Online Access:	https://doi.org/10.1186/s40168-023-01713-9

Similar Items

Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis: A Systematic Review
by: Frederik Cold, et al.
Published: (2020-09-01)

Safety and Efficacy of Fecal Microbiota Transplant in Chronic Pouchitis—A Systematic Review With Meta-Analysis
by: Tamara Kahan, et al.
Published: (2023-01-01)

Fecal microbiota transplantation from a healthy pouch donor for chronic pouchitis: a proof-of-concept study
by: Sabrina Just Kousgaard, et al.
Published: (2025-12-01)

Fecal Microbiota Transplantation for Chronic Pouchitis: A Systematic Review and Meta-Analysis
by: Magnus Chun, et al.
Published: (2024-11-01)

Pouchitis: Clinical Features, Diagnosis, and Treatment
by: Gionchetti P, et al.
Published: (2021-07-01)

Fecal calprotectin as an indicator in risk stratification of pouchitis following ileal pouch–anal anastomosis for ulcerative colitis
by: Rui-Bin Li, et al.
Published: (2023-12-01)

Microbiota and mucosal gene expression of fecal microbiota transplantation or placebo treated patients with chronic pouchitis
by: Anna K. Hartikainen, et al.
Published: (2024-12-01)

A review of engraftment assessments following fecal microbiota transplant
by: Chloe Herman, et al.
Published: (2025-12-01)

Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis
by: Francesca Bernardi, et al.
Published: (2024-12-01)

Key Focus Areas in Pouchitis Therapeutic Status: A Narrative Review
by: Seyed Mohammad Kazem Hosseini-Asl, et al.
Published: (2024-08-01)

Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab
by: Diana Martins, et al.
Published: (2018-02-01)

Chronic Antibiotic-Refractory Pouchitis: Management Challenges
by: Outtier A, et al.
Published: (2021-06-01)

Comprehensive systematic review and pooled analysis of real‐world studies evaluating immunomodulator and biologic therapies for chronic pouchitis treatment
by: Emi Khoo, et al.
Published: (2023-12-01)

Incidence, Risk Factors, and Outcomes of Chronic Antibiotic-Refractory Pouchitis in Korean Patients with Ulcerative Colitis
by: Ji Eun Baek, et al.
Published: (2025-05-01)

Prevalence of Active Pouch Symptoms and Patient Perception of Symptom Control and Quality of Life in an Outpatient Practice
by: Polly Kirsch, et al.
Published: (2024-01-01)

Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies
by: Suresh C. Bokoliya, et al.
Published: (2021-09-01)

Dysbiosis in Metabolic Genes of the Gut Microbiomes of Patients with an Ileo-anal Pouch Resembles That Observed in Crohn's Disease
by: Vadim Dubinsky, et al.
Published: (2021-04-01)

Duodenitis associated with ulcerative colitis and pouchitis after total colectomy successfully treated with upadacitinib: A case report
by: Kentaro Kojima, et al.
Published: (2025-04-01)

Pouchitis Is Associated with Paneth Cell Dysfunction and Ameliorated by Exogenous Lysosome in a Rat Model Undergoing Ileal Pouch Anal Anastomosis
by: Yi Xu, et al.
Published: (2023-11-01)

Risk Factors and Postoperative Outcomes in Pouchitis Following Restorative Proctocolectomy: An 18-Year Single-Center Study
by: Luisa Bertin, et al.
Published: (2024-12-01)

Engraftment of Bacteria after Fecal Microbiota Transplantation Is Dependent on Both Frequency of Dosing and Duration of Preparative Antibiotic Regimen
by: Vancheswaran Gopalakrishnan, et al.
Published: (2021-06-01)

A Pilot study on Prediction of Pouchitis in Ulcerative Colitis Patients by Decision Tree Method Versus Logistic Regression Analysis
by: Saeedeh Pourahmad, et al.
Published: (2013-09-01)

Fecal microbiota transfer to treat ulcerative colitis: Medical and legal challenges
by: Arndt Steube, et al.
Published: (2023-03-01)

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient
by: Aretha Fiebig, et al.
Published: (2024-01-01)

Disentangle beneficial effects of strain engraftment after fecal microbiota transplantation in subjects with MetSyn
by: Eduard W. J. van der Vossen, et al.
Published: (2024-12-01)

Association between serum tumor necrosis factor-alpha level and the efficacy of infliximab for refractory pouchitis after restorative proctocolectomy in patients with ulcerative colitis
by: Motoi Uchino, et al.
Published: (2017-10-01)

Engraftment Syndrome: A Retrospective Analysis of the Experience at a Tertiary Care Institute
by: Raja Pramanik, et al.
Published: (2019-05-01)

Synergistic gut microbiome-mediated degradation of Astragalus membranaceus polysaccharides and Codonopsis pilosula polysaccharides into butyric acid: a metatranscriptomic analysis
by: XinQian Rong, et al.
Published: (2025-07-01)

In Vitro Preliminary Evaluation of a New Rifamycin In Situ Gelling Formulation for Pouchitis Treatment
by: Caterina Aiello, et al.
Published: (2025-02-01)

Are Small Molecules Effective in Treating Inflammatory Pouch Disorders Following Ileal Pouch-Anal Anastomosis for Ulcerative Colitis? Here Is Where We Stand
by: Antonietta Gerarda Gravina, et al.
Published: (2024-09-01)

The altered TBI fecal microbiome is stable and functionally distinct
by: Richard B. Pyles, et al.
Published: (2024-03-01)

Utility of Procalcitonin in the Engraftment Phase of Hematopoietic Stem Cell Transplantation in Children
by: Koray Yalçın, et al.
Published: (2022-09-01)

Microbiome compositional changes and clonal engraftment in a phase 3 trial of fecal microbiota, live-jslm for recurrent Clostridioides difficile infection
by: Josh Claypool, et al.
Published: (2025-12-01)

Oral administration of Lactobacillus casei DG® after ileostomy closure in restorative proctocolectomy: a randomized placebo-controlled trial (microbiota and immune microenvironment in pouchitis -MEP1)
by: Imerio Angriman, et al.
Published: (2024-12-01)

Autologous stem cell rescue recipient with neutrophil tissue delivery detected prior to blood engraftment: A case report
by: Bushra Tbakhi, et al.
Published: (2020-07-01)

Prophylactic intravenous immunoglobulin use in allogeneic stem cell transplantation; does intravenous immunoglobulin affect survival, sepsis, and engraftment time?
by: Ahmet Kaya, et al.
Published: (2024-12-01)

Preoperative Endoscopic Activity Predicts the Occurrence of Pouchitis After Ileal Pouch–Anal Anastomosis in Ulcerative Colitis: A Multicenter Retrospective Study in China
by: Weimin Xu, et al.
Published: (2021-09-01)

Metatranscriptomic identification of novel RNA viruses from raccoon dog (Nyctereutes procyonoides) feces in Japan
by: Mami Oba, et al.
Published: (2025-02-01)

Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice
by: Torben Sølbeck Rasmussen, et al.
Published: (2023-12-01)

Resolution of long-term severe irritable bowel syndrome following fecal microbiota transplantation: A case report and microbiota analysis
by: Elena Montenegro-Borbolla, et al.
Published: (2025-12-01)