Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms

We have studied the neurotoxicity of amyloid-beta (Aβ) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout the photoreceptor layer and the inner nuclear layer but not in the ganglion cell layer at 48 h after injection of Aβ1-42 compared to vehicle...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Desmond T. Walsh, Rosa M. Montero, Laura G. Bresciani, Angela Y.T. Jen, Pascale D. Leclercq, Debbie Saunders, Ahmed N. EL-Amir, Lukemann Gbadamoshi, Stephen M. Gentleman, Ling-Sun Jen
Format:	Article
Language:	English
Published:	Elsevier 2002-06-01
Subjects:	amyloid-beta neurotoxicity retinal neurons Müller cells glial dysfunction neurodegeneration
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996102904857