A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis

Summary: Genomics studies have detected numerous genetic alterations in esophageal squamous cell carcinoma (ESCC). However, the functions of these mutations largely remain elusive, partially due to a lack of feasible animal models. Here, we report a convenient platform with CRISPR-Cas9-mediated intr...

Full description

Bibliographic Details

Published in:	Cell Reports
Main Authors:	Jian Wang, Jiajia Du, Xiangmeng Luo, Linjie Guo, Yixin Liu, Jianfeng Zhou, Yang Zou, Zhenghao Lu, Xiangyu Pan, Xuelan Chen, Ailing Zhong, Xudong Wan, Lu Wang, Hongyu Liu, Siqi Dai, Shiyu Zhang, Xingyu Xiong, Ping Tan, Manli Wang, Baohong Wu, Qi Zhang, Yingjie Wang, Mengsha Zhang, Runda Lu, Huahang Lin, Yuan Li, Yaxin Li, Zongkai Han, Longqi Chen, Bing Hu, Yu Liu, Feifei Na, Chong Chen
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Subjects:	CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724013032