PKR-mediated stress response enhances dengue and Zika virus replication

ABSTRACT The mechanisms by which flaviviruses use non-canonical translation to support their replication in host cells are largely unknown. Here, we investigated how the integrated stress response (ISR), which promotes translational arrest by eIF2ɑ phosphorylation (p-eIF2ɑ), regulates flavivirus rep...

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Bibliographic Details
Published in:mBio
Main Authors: Taissa Ricciardi-Jorge, Edroaldo Lummertz da Rocha, Edgar Gonzalez-Kozlova, Gabriela Flavia Rodrigues-Luiz, Brian J. Ferguson, Trevor Sweeney, Nerea Irigoyen, Daniel Santos Mansur
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Subjects:
dengue virus
Zika virus
innate immunity
protein translation
PKR
Online Access:https://journals.asm.org/doi/10.1128/mbio.00934-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00934-23

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