Activity-dependent synapse elimination requires caspase-3 activation

During brain development, synapses are initially formed in excess and are later eliminated in an activity-dependent manner. Weak synapses are preferentially removed, but the mechanism linking neuronal activity to synapse removal is unclear. Here, we show that, in the developing mouse visual pathway,...

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Bibliographic Details

Published in:	eLife
Main Authors:	Zhou Yu, Andrian Gutu, Namsoo Kim, Erin K O'Shea
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-06-01
Subjects:	synapse elimination synaptic activity caspase-3 microglia
Online Access:	https://elifesciences.org/articles/101779