Enhanced Solubility of Ibuprofen by Complexation with β-Cyclodextrin and Citric Acid

The ability of β-CD to form inclusion complexes with ibuprofen (IBU) and at the same time to make a two-phase system with citric acid was explored in the present study for achieving improved solubility and dissolution rate of IBU. Mechanical milling as well as mechanical milling combined with therma...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Tsveta Sarafska, Stanislava Ivanova, Todor Dudev, Christo Tzachev, Vesselin Petrov, Tony Spassov
Format:	Article
Language:	English
Published:	MDPI AG 2024-04-01
Subjects:	Ibuprofen cyclodextrin citric acid inclusion complex solubility dissolution rate
Online Access:	https://www.mdpi.com/1420-3049/29/7/1650