Stable long-term germline transmission of GFP transgenic rat via PiggyBac transposon mediated gene transfer

Abstract Transgene silencing provides a significant challenge in animal model production via gene engineering using viral vectors or transposons. Selecting an appropriate strategy, contingent upon the species is crucial to circumvent transgene silencing, necessitating long-term observation of in viv...

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Bibliographic Details
Published in:BMC Veterinary Research
Main Authors: Beom-Jin Jeon, Dong-Hyeok Kwon, Gyeong-min Gim, Hee-Kyoung Kim, Jeong-Hwa Lee, Goo Jang
Format: Article
Language:English
Published: BMC 2024-06-01
Subjects:
Germline Transmission
GFP-Rats
Resources
Transgene Silencing
Transposon
Online Access:https://doi.org/10.1186/s12917-024-04123-7

Internet

https://doi.org/10.1186/s12917-024-04123-7

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