Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities

A concise and scalable synthetic route for optically pure (4<i>S</i>) and (4<i>R</i>)-5-(3′,4′-dihydroxyphenyl)-γ-valerolactones (DHPVs), catechin metabolites, has been developed via the efficient construction of a γ-valerolactone moiety from hexenol. Noticeably, the differen...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Joonseong Hur, A-Ram Kim, Hyun Su Kim, Changjin Lim, Taewoo Kim, Tae-Aug Kim, Jaehoon Sim, Young-Ger Suh
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	catechin metabolite γ-valerolactone concise synthesis skin wrinkle-reducing activity
Online Access:	https://www.mdpi.com/1420-3049/25/8/1970