A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels

Lipid regulation of ion channels by low-abundance signaling lipids phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid (PA) has emerged as a central cellular mechanism for controlling ion channels and the excitability of nerves. A lack of robust assays suitable for facile detection of...

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出版年:	Cell Reports
主要な著者:	Cerrone Cabanos, Miao Wang, Xianlin Han, Scott B. Hansen
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2017-08-01
主題:	PIP2 TREK TRAAK Kir potassium channel fluorescent assay lipid binding arachidonic acid signaling lipid phosphatidic acid
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124717310008