RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication
The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been tested. Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth...
| Published in: | The Journal of Clinical Investigation |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2024-05-01
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| Subjects: | |
| Online Access: | https://doi.org/10.1172/JCI167419 |