Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease

Summary: Sarcopenia is a common and devastating condition in patients with chronic kidney disease (CKD). Here, we provide evidence that the kidney-muscle crosstalk in sarcopenia is mediated by reduced insulin sensitivity and the activation of the muscle-specific isoform of AMP deaminase, AMPD1. By u...

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Bibliographic Details

Published in:	iScience
Main Authors:	Ana Andres-Hernando, Christina Cicerchi, Gabriela E. Garcia, David J. Orlicky, Peter Stenvinkel, Richard J. Johnson, Miguel A. Lanaspa
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Subjects:	Biological sciences Physiology Pathophysiology Cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223004327