Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of ion conductance in the presence of a prolonged voltage stimulus, termed slow inactivation, but the atomic determinants that regulate the kine...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Stephan A Pless, Jason D Galpin, Ana P Niciforovic, Harley T Kurata, Christopher A Ahern
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2013-12-01
Subjects:	neuroscience ion channel gating unnatural amino acid hydrogen bond channel inactivation molecular timer
Online Access:	https://elifesciences.org/articles/01289