Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’s Disease

A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer’s disease (AD). Most of the compounds showed weak...

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出版年:	Frontiers in Chemistry
主要な著者:	Ladan Pourabdi, Tuba Tüylü Küçükkılınç, Fatemeh Khoshtale, Beyza Ayazgök, Hamid Nadri, Farid Farokhi Alashti, Hamid Forootanfar, Tayebeh Akbari, Mohammad Shafiei, Alireza Foroumadi, Mohammad Sharifzadeh, Mehdi Shafiee Ardestani, M. Saeed Abaee, Loghman Firoozpour, Mehdi Khoobi, Mohammad M. Mojtahedi
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-01-01
主題:	lipoxygenase inhibition 3-arylcoumarins neuroprotective agents Alzeihmer’s disease anti-amyloid aggregation
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fchem.2021.810233/full