Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

Antibiotic tolerance in Mycobacterium tuberculosis reduces bacterial killing, worsens treatment outcomes, and contributes to resistance. We studied rifampicin tolerance in isolates with or without isoniazid resistance (IR). Using a minimum duration of killing assay, we measured rifampicin survival i...

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Bibliographic Details

Published in:	eLife
Main Authors:	Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat, Do Dang Anh Thu, Nguyen Le Quang, Le Pham Tien Trieu, Hoang Ngoc Nhung, Vu Thi Ngoc Ha, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Huu Lan, Maxine Caws, Guy E Thwaites, Babak Javid, Nguyen Thuy Thuong
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-09-01
Subjects:	tuberculosis mycobacterium rifampicin tolerance
Online Access:	https://elifesciences.org/articles/93243