Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor

Abstract The receptor tyrosine kinase EphA2 drives cancer malignancy by facilitating metastasis. EphA2 can be found in different self-assembly states: as a monomer, dimer, and oligomer. However, we have a poor understanding regarding which EphA2 state is responsible for driving pro-metastatic signal...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Ryan J. Schuck, Alyssa E. Ward, Amita R. Sahoo, Jennifer A. Rybak, Robert J. Pyron, Thomas N. Trybala, Timothy B. Simmons, Joshua A. Baccile, Ioannis Sgouralis, Matthias Buck, Rajan Lamichhane, Francisco N. Barrera
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Online Access:	https://doi.org/10.1038/s42003-025-07786-6