Anti-tumor drug FTY720 regulates p53-dependent transcription

Objective To explore whether anti-tumor drug FTY720 participates in regulation of p53-dependent gene transcription and to evaluate the potential roles of FTY720-p53 axis in the modulation of cellular biological processes. Methods CRISPR-Cas9 technique was used to generate a p53-knockout (p53-KO) c...

Full description

Bibliographic Details

Published in:	Jichu yixue yu linchuang
Main Author:	YAO Han, XU Wen-bin, WANG Dong-lai
Format:	Article
Language:	Chinese
Published:	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2021-03-01
Subjects:	p53|fty720|u2os|gene expressional regulation|bioinformatic analysis
Online Access:	http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201315.pdf