Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia

Markers of the kynurenine pathway were studied in postmortem frontal cortex obtained from individuals with schizophrenia and controls. Quantitative endpoint RT-PCR was used to measure mRNA transcripts. Of the two enzymes capable of catalyzing the first step in the pathway, tryptophan 2,3-dioxygenase...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Christine L Miller, Ida C Llenos, Jeanette R Dulay, Meliza M Barillo, Robert H Yolken, Serge Weis
Format:	Article
Language:	English
Published:	Elsevier 2004-04-01
Subjects:	Psychosis Human Tryptophan pyrrolase TDO2 INDO Indoleamine dioxygenase
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996104000026