Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in primary sclerosing cholangitis

Cellular senescence and biliary fibrosis are prototypical features of obliterative cholangiopathies, such as primary sclerosing cholangitis (PSC). Telomere dysfunction can lead to senescence either through telomere erosion or damaged telomeres. Our goal was to investigate a mechanistic relationship...

詳細記述

書誌詳細

出版年:	JCI Insight
主要な著者:	Nidhi Jalan-Sakrikar, Abid Anwar, Usman Yaqoob, Can Gan, Anthony B. Lagnado, Alexander Q. Wixom, Diana Jurk, Robert C. Huebert
フォーマット:	論文
言語:	英語
出版事項:	American Society for Clinical investigation 2023-10-01
主題:	Gastroenterology Hepatology
オンライン･アクセス:	https://doi.org/10.1172/jci.insight.170320