RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability

Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome. RNA polymerase I (RNAPI) is responsible for massive rRNA production, and nascent rRNA is co-transcriptionally assem...

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Bibliographic Details

Published in:	RNA Biology
Main Authors:	Christophe Normand, Christophe Dez, Lise Dauban, Sophie Queille, Sarah Danché, Sarra Abderrahmane, Frederic Beckouet, Olivier Gadal
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	ribosomal RNA Transcription Genome stability S.cerevisiae
Online Access:	https://www.tandfonline.com/doi/10.1080/15476286.2024.2381910