Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei.

Trypanosoma brucei, causing African sleeping-sickness, exploits quorum-sensing (QS) to generate the 'stumpy forms' necessary for the parasite's transmission to tsetse-flies. These quiescent cells are generated by differentiation in the bloodstream from proliferative slender forms. Usi...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Eva Rico, Alasdair Ivens, Lucy Glover, David Horn, Keith R Matthews
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-03-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006279&type=printable