Identification of the shared genetic architecture underlying seven autoimmune diseases with GWAS summary statistics

BackgroundThe common clinical symptoms and immunopathological mechanisms have been observed among multiple autoimmune diseases (ADs), but the shared genetic etiology remains unclear.MethodsGWAS summary statistics of seven ADs were downloaded from Open Targets Genetics and Dryad. Linkage disequilibri...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yuping Wang, Yongli Yang, Xiaocan Jia, Chenyu Zhao, Chaojun Yang, Jingwen Fan, Nana Wang, Xuezhong Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	genetic architecture autoimmune diseases multiple adaptive association tests pleiotropic genome-wide association studies
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303675/full