Preventing type 1 diabetes in late-stage pre-diabetic NOD mice with insulin: A central role for alum as adjuvant

BackgroundRestoration of immune tolerance to disease-relevant antigens is an appealing approach to prevent or arrest an organ-specific autoimmune disease like type 1 diabetes (T1D). Numerous studies have identified insulin as a key antigen of interest to use in such strategies, but to date, the succ...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Pieter-Jan Martens, Darcy Ellis, Ylke Bruggeman, Marijke Viaene, Jos Laureys, Luc Teyton, Chantal Mathieu, Conny Gysemans
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	type 1 diabetes mellitus antigen-specific immunomodulation prevention insulin
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2022.1023264/full