Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection.

Group A Streptococcus (GAS, Streptococcus pyogenes) is a professional human pathogen that commonly infects the skin. Keratinocytes are one of the first cells to contact GAS, and by inducing inflammation, they can initiate the earliest immune responses to pathogen invasion. Here, we characterized the...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Anders F Johnson, Jenna S Sands, Keya M Trivedi, Raedeen Russell, Doris L LaRock, Christopher N LaRock
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-04-01
Online Access:	https://doi.org/10.1371/journal.ppat.1011321