TMEM219 regulates the transcription factor expression and proliferation of beta cells

Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the “holy grail” for those patients with exhausted beta cell mass. Here we are demonstrating that the pro-apoptotic receptor TMEM219 is expresse...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Francesca D’Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Paolo Fiorina
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	type 1 diabetes endocrine progenitors TMEM219 IGFBP3 islets mature and immature beta cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1306127/full