Left-handed DNA for efficient highly multiplexed imaging at single-protein resolution

Abstract Multiplexed super-resolution microscopy enables spatial proteomics at single-protein resolution, but current methods often depend on secondary labels, complicating implementation and limiting throughput. We introduce a streamlined approach that combines speed-optimized DNA-PAINT sequences w...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Eduard M. Unterauer, Eva-Maria Schentarra, Isabelle Pachmayr, Taisha Tashrin, Jisoo Kwon, Sebastian Strauss, Kristina Jevdokimenko, Rafal Kowalewski, Felipe Opazo, Eugenio F. Fornasiero, Luciano A. Masullo, Ralf Jungmann
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Online Access:	https://doi.org/10.1038/s41467-025-64228-x