Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

IntroductionNatural killer 92 (NK-92) cells are an attractive therapeutic approach as alternative chimeric antigen receptor (CAR) carriers, different from T cells, once they can be used in the allogeneic setting. The modest in vivo outcomes observed with NK-92 cells continue to present hurdles in su...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Renata Nacasaki Silvestre, Jiri Eitler, Julia Teixeira Cottas de Azevedo, Mariane Cariati Tirapelle, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Kamilla Swiech, Dimas Tadeu Covas, Rodrigo T. Calado, Paola Ortiz Montero, Kelen Cristina Ribeiro Malmegrim, Marxa L. Figueiredo, Torsten Tonn, Virginia Picanço-Castro
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Subjects:	CAR-NK cells NK-92 adoptive cell therapy IL-15 IL-15 receptor B-cell malignances
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226518/full