Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

ObjectiveMesothelin (MSLN) is an attractive target for anticancer therapeutics and bioimaging reagents that utilize antibodies. This study was aimed at developing a novel human anti-MSLN single-domain antibody that exclusively binds to the membrane-attached MSLN using transgenic mice generating huma...

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Bibliographic Details

Published in:	Frontiers in Chemical Biology
Main Authors:	Rick Janssens, Rien van Haperen, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, Dubravka Drabek
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	mesothelin (MSLN) heavy-chain-only antibody (HCAb) OVCAR-3 tumor radioimaging SPECT and PET imaging
Online Access:	https://www.frontiersin.org/articles/10.3389/fchbi.2024.1408621/full