The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity

Abstract Maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) is critical for vascular homeostasis. However, the role of the 3D chromatin architecture in regulating VSMC identity remains elusive. A genome-scale CRISPR screen identifies LEMD3 as a potential regulator to maint...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Wenqiang Li, Yunxi Liao, Zhujiang Liu, Longjian Niu, Jiaqi Huang, Yiting Jia, Ran Xu, Sudun Guan, Zhenhui Liang, Yiran Li, Hao Wu, Shirong Zhu, Liao Tan, Fang Yu, Zhihua Wang, Luyang Sun, Dongyu Zhao, Wei Kong, Yi Fu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Online Access:	https://doi.org/10.1038/s41467-025-63876-3