Selection and characterization of DNA aptamers targeting the surface Borrelia protein CspZ with high-throughput cross-over SELEX

Abstract Lyme borreliosis (LB) is the most prevalent tick-borne illness, with an estimated 700 000 cases annually in the United States and Europe. The LB diagnosis based on a two-tiered serology remains controversial due to its indirect nature and low sensitivity during the early stage of the diseas...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Mickaël Guérin, Marylène Vandevenne, André Matagne, Willy Aucher, Julien Verdon, Emmeline Paoli, Jules Ducrotoy, Stéphane Octave, Bérangère Avalle, Irene Maffucci, Séverine Padiolleau-Lefèvre
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Online Access:	https://doi.org/10.1038/s42003-025-08034-7