Mechanistic Insights into Vorinostat as a Repositioned Modulator of TACE-Mediated TNF-α Signaling via MAPK and NFκB Pathways

Vorinostat, an FDA-approved histone deacetylase inhibitor, was evaluated for its potential anti-inflammatory activity through modulation of TACE (ADAM17)-mediated TNF-α signaling. The study was conducted using LPS-stimulated RAW264.7 macrophages. TACE enzymatic activity was assessed by a fluorogenic...

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Bibliographic Details

Published in:	Current Issues in Molecular Biology
Main Authors:	Jinyoung Park, Muhammad Yasir, Jongseon Choe, Jin-Hee Han, Eun-Taek Han, Won Sun Park, Wanjoo Chun
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	vorinostat TACE (ADAM17) TNF-α MAPK/NFκB drug repositioning
Online Access:	https://www.mdpi.com/1467-3045/47/9/720