Mechanistic Insights into Vorinostat as a Repositioned Modulator of TACE-Mediated TNF-α Signaling via MAPK and NFκB Pathways

Vorinostat, an FDA-approved histone deacetylase inhibitor, was evaluated for its potential anti-inflammatory activity through modulation of TACE (ADAM17)-mediated TNF-α signaling. The study was conducted using LPS-stimulated RAW264.7 macrophages. TACE enzymatic activity was assessed by a fluorogenic...

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Bibliographic Details
Published in:Current Issues in Molecular Biology
Main Authors: Jinyoung Park, Muhammad Yasir, Jongseon Choe, Jin-Hee Han, Eun-Taek Han, Won Sun Park, Wanjoo Chun
Format: Article
Language:English
Published: MDPI AG 2025-09-01
Subjects:
vorinostat
TACE (ADAM17)
TNF-α
MAPK/NFκB
drug repositioning
Online Access:https://www.mdpi.com/1467-3045/47/9/720

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