Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Abstract Although pathological cardiac hypertrophy is a key driver of heart failure, the underlying mechanisms remain incompletely elucidated. This study investigates the role and mechanism of deubiquitinating enzyme (DUB) ubiquitin‐specific protease 20 (USP20) in cardiac hypertrophy. Transcriptomic...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin
Format:	Article
Language:	English
Published:	Wiley 2025-06-01
Subjects:	cardiac hypertrophy cardiomyocyte deubiquitinating enzyme signal transducer and activator of transcription 3 ubiquitin‐specific protease 20
Online Access:	https://doi.org/10.1002/advs.202416478