Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive. Recent studies have suggested novel roles of the habenula in...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Ya-wei Zhao, Yu-qin Pan, Ming-ming Tang, Wen-juan Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Subjects:	depression p38 neuroinflammation habenula fluoxetine SB203580
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00511/full