Prognostic implications and characterization of tumor-associated tertiary lymphoid structures genes in pancreatic cancer

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive cancers, with rising incidence and limited responsiveness to immunotherapy due to its highly suppressive tumor microenvironment (TME). Tertiary lymphoid structures (TLS), ectopic formation structures of immune c...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Enkui Zhang, Yongsu Ma, Zonghao Liu, Jixin Zhang, Weikang Liu, Yiran Chen, Guangnian Liu, Xinxin Liu, Fusheng Zhang, Yu Zhu, Yinmo Yang, Xiaodong Tian
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Pancreatic cancer Tertiary lymphoid structures Tumor microenvironment Prognostic signature Characterization
Online Access:	https://doi.org/10.1186/s12967-025-06152-8