A bivalent spike-targeting nanobody with anti-sarbecovirus activity

Abstract The continued emergence and zoonotic threat posed by coronaviruses highlight the urgent need for effective antiviral strategies with broad reactivity to counter new emerging strains. Nanobodies (or single-domain antibodies) are promising alternatives to traditional monoclonal antibodies, du...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Iris C. Swart, Oliver J. Debski-Antoniak, Aneta Zegar, Thijs de Bouter, Marianthi Chatziandreou, Max van den Berg, Ieva Drulyte, Krzysztof Pyrć, Cornelis A. M. de Haan, Daniel L. Hurdiss, Berend-Jan Bosch, Sabrina Oliveira
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Nanobodies Sarbecovirus SARS-CoV-2 Spike trimer dimer formation Cryo-EM Nanobody multimerization
Online Access:	https://doi.org/10.1186/s12951-025-03243-y