Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

Abstract Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human papilloma virus (HPV) oncogenes and loss of retinoblastoma (RB) protein function has been reported to increase sensitivity to AURKB inh...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Shivam Vora, Ariel Andrew, Ramyashree Prasanna Kumar, Deborah Nazareth, Alexis Bonfim-Melo, Yoon Lim, Xin Yee Ong, Madushan Fernando, Yaowu He, John D. Hooper, Nigel AJ McMillan, Jelena Urosevic, Jon Travers, Jamal Saeh, Sharad Kumar, Mathew JK Jones, Brian Gabrielli
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-11-01
Online Access:	https://doi.org/10.1038/s41419-024-07204-5