Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative homeostasis and imbalanced dNTP pools

Ribonucleotide reductase (RNR) catalyzes the synthesis of four deoxyribonucleoside triphosphates (dNTPs), which are essential for DNA replication. Although dNTP imbalances reduce replication fidelity and elevate mutation rates, the impact of RNR dysfunction on Mycobacterium tuberculosis (Mtb) physio...

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Bibliographic Details

Published in:	Emerging Microbes and Infections
Main Authors:	Xiao Zhang, Yuchang Di, Yu Zhang, Youwei Hu, Mingzhe Chi, Jian Kang, Yuqing Zheng, Hengyu Wang, Yu Wang, Jiazhen Chen, Xuelian Zhang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Mycobacterium ribonucleotide reductase oxidative homeostasis dNTPs balance genomic stability mutation
Online Access:	https://www.tandfonline.com/doi/10.1080/22221751.2025.2480698