DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.

Tumor cells might resist therapy with ionizing radiation (IR) by non-homologous end-joining (NHEJ) of IR-induced double-strand breaks. One of the key players in NHEJ is DNA-dependent protein kinase (DNA-PK). The catalytic subunit of DNA-PK, i.e. DNA-PKcs, can be inhibited with the small-molecule inh...

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الحاوية / القاعدة:	PLoS ONE
المؤلفون الرئيسيون:	M Emmy M Dolman, Ida van der Ploeg, Jan Koster, Laurel Tabe Bate-Eya, Rogier Versteeg, Huib N Caron, Jan J Molenaar
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Public Library of Science (PLoS) 2015-01-01
الوصول للمادة أونلاين:	http://europepmc.org/articles/PMC4696738?pdf=render