GeTallele: A Method for Analysis of DNA and RNA Allele Frequency Distributions

Variant allele frequencies (VAF) are an important measure of genetic variation that can be estimated at single-nucleotide variant (SNV) sites. RNA and DNA VAFs are used as indicators of a wide-range of biological traits, including tumor purity and ploidy changes, allele-specific expression and gene-...

Full description

Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Piotr Słowiński, Muzi Li, Paula Restrepo, Nawaf Alomran, Liam F. Spurr, Christian Miller, Krasimira Tsaneva-Atanasova, Anelia Horvath
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Subjects:	variant allele fraction (VAF) RNA—DNA earth mover's distance (EMD) circos plot farey sequence
Online Access:	https://www.frontiersin.org/article/10.3389/fbioe.2020.01021/full