A cell-impermeable kinase inhibitor uncovers outside-in signaling pathways that promote HIV-1 infection

ABSTRACT Studies of herpes simplex virus (HSV) entry revealed a previously unrecognized “outside-in” signaling pathway involving phosphatidylserine (PS) scrambling and associated translocation and subsequent extracellular activation of canonical intracellular proteins, including Akt. We hypothesized...

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Bibliographic Details
Published in:Journal of Virology
Main Authors: Kelsey Vinzant, Natalia Cheshenko, Heng Pan, Ronald Cutler, Joshua N. Buckler, Andreas Luxenburger, Lawrence D. Harris, Jeffrey R. Johnson, Steven C. Almo, Betsy C. Herold
Format: Article
Language:English
Published: American Society for Microbiology 2026-06-01
Subjects:
TMEM16F
glypican-1
T cells
kinase inhibitor
HIV-1
Online Access:https://journals.asm.org/doi/10.1128/jvi.00160-26

Internet

https://journals.asm.org/doi/10.1128/jvi.00160-26

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