Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment

Sorafenib (Sor), a multi-kinase inhibitor, serves as the first-line systemic therapeutic drug for advanced hepatocellular carcinoma (HCC). Unfortunately, clinical benefit was confirmed in only a minority of patients, limiting clinical application of Sor. Using nanotechnology to enhance the therapeut...

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Bibliographic Details

Published in:	Materials Today Bio
Main Authors:	Yuanliang Yan, Jun Hu, Ning Han, Hai-Tao Li, Xiaoxin Yang, Liu-Gen Li, Zhijie Xu, Fada Xia, Jie Li, Tong-fei Li, Ruochan Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Metal-organic framework Sorafenib Ferroptosis Tumor immune microenvironment Hepatocellular carcinoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006425004089