Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy

<b>Background:</b> Tauopathy has been identified as a prevalent causative agent of neurodegenerative diseases, including frontotemporal dementia with parkinsonism-17 (FTDP-17). This rare hereditary neurodegenerative condition is characterised by the manifestation of parkinsonism and beha...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Julia A. Nadtochy, Sergey P. Medvedev, Elena V. Grigor’eva, Sophia V. Pavlova, Julia M. Minina, Anton V. Chechushkov, Anastasia A. Malakhova, Liudmila V. Kovalenko, Suren M. Zakian
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	mitochondrial dysfunction MitoTimer biosensor induced pluripotent stem cells CRISPR/Cas9 <i>MAPT:c.2013T > G</i> frontotemporal dementia with parkinsonism-17
Online Access:	https://www.mdpi.com/2227-9059/13/3/550