Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex

Complexin regulates spontaneous and activates Ca2+-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of complexin-1 bound to the ternary SNARE comple...

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Bibliographic Details

Published in:	eLife
Main Authors:	Ucheor B Choi, Minglei Zhao, Yunxiang Zhang, Ying Lai, Axel T Brunger
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-06-01
Subjects:	synaptic vesicle fusion neurotransmitter release calcium triggering
Online Access:	https://elifesciences.org/articles/16886